Journal article
A comparison of automated segmentation and manual tracing in estimating hippocampal volume in ischemic stroke and healthy control participants
MS Khlif, N Egorova, E Werden, A Redolfi, M Boccardi, CS DeCarli, E Fletcher, B Singh, Q Li, L Bird, A Brodtmann
Neuroimage Clinical | ELSEVIER SCI LTD | Published : 2019
Abstract
Manual quantification of the hippocampal atrophy state and rate is time consuming and prone to poor reproducibility, even when performed by neuroanatomical experts. The automation of hippocampal segmentation has been investigated in normal aging, epilepsy, and in Alzheimer's disease. Our first goal was to compare manual and automated hippocampal segmentation in ischemic stroke and to, secondly, study the impact of stroke lesion presence on hippocampal volume estimation. We used eight automated methods to segment T1-weighted MR images from 105 ischemic stroke patients and 39 age-matched controls sampled from the Cognition And Neocortical Volume After Stroke (CANVAS) study. The methods were: A..
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Awarded by National Institute on Aging
Funding Acknowledgements
[ "This work was supported by the National Health and Medical Research Council project grant (APP1020526), the Brain Foundation, Wicking Trust, Collie Trust, and Sidney and Fiona Myer Family Foundation.", "The Florey Institute of Neuroscience and Mental Health acknowledges the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant. The authors acknowledge the facilities, and the scientific and technical assistance of the National Imaging Facility at the Florey Node." ]